Robust Driving Forces for Transmembrane Helix Packing
نویسندگان
چکیده
منابع مشابه
Robust driving forces for transmembrane helix packing.
The packing structures of transmembrane helices are traditionally attributed to patterns in residues along the contact surface. In this view, besides keeping the helices confined in the membrane, the bilayer has only a minor effect on the helices structure. Here, we use two different approaches to show that the lipid environment has a crucial effect in determining the cross-angle distribution o...
متن کاملSupporting Material: Robust Driving Forces for Transmembrane Helix Packing
• We refine the database to include only proteins with TM helices. This includes alpha-helical polytopic and alpha-helical bitopic OPM classes as of September 2011 (357 TM proteins, 261 unique). The full list of MPs is available in Table S2. • We extract the structure of each such protein from the database. • We extract other supporting information on the protein such as the hydrophobic thickne...
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The vast majority of membrane proteins are anchored to biological membranes through hydrophobic α-helices. Sequence analysis of high-resolution membrane protein structures show that ionizable amino acid residues are present in transmembrane (TM) helices, often with a functional and/or structural role. Here, using as scaffold the hydrophobic TM domain of the model membrane protein glycophorin A ...
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α-helical transmembrane (TM) proteins play an important role in many critical and diverse biological processes, and specific associations between TM helices are important determinants for membrane protein folding, dynamics and function. In order to gain insights into the above phenomena, it is necessary to investigate different types of helix-packing modes and interactions. However, such inform...
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Methods that predict membrane helices have become increasingly useful in the context of analyzing entire proteomes, as well as in everyday sequence analysis. Here, we analyzed 27 advanced and simple methods in detail. To resolve contradictions in previous works and to reevaluate transmembrane helix prediction algorithms, we introduced an analysis that distinguished between performance on redund...
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ژورنال
عنوان ژورنال: Biophysical Journal
سال: 2012
ISSN: 0006-3495
DOI: 10.1016/j.bpj.2012.08.035